2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-141028
    N,N'-DME-N,N'-Bis-PEG2-acid 2062663-61-8
    N,N'-DME-N,N'-Bis-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N,N'-DME-N,N'-Bis-PEG2-acid
  • HY-138433
    Benzyl-PEG1-propanol 131326-24-4
    Benzyl-PEG1-propanol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG1-propanol
  • HY-132105
    Benzyl-PEG6-THP 230620-73-2
    Benzyl-PEG6-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG6-THP
  • HY-140360
    m-PEG10-Tos 211859-75-5
    m-PEG10-Tos is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    m-PEG10-Tos
  • HY-132059
    Azido-PEG13-azide
    Azido-PEG13-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG13-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG13-azide
  • HY-133461
    Tetrazine-Ph-NHCO-PEG6-NH-Boc
    Tetrazine-Ph-NHCO-PEG6-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Tetrazine-Ph-NHCO-PEG6-NH-Boc is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
    Tetrazine-Ph-NHCO-PEG6-NH-Boc
  • HY-140853
    Azido-PEG3-CH2CO2Me 1253389-31-9
    Azido-PEG3-CH2CO2Me is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-CH2CO2Me is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-CH2CO2Me
  • HY-W096151
    Chloroacetamido-C-PEG3-C3-NHBoc 934164-55-3
    Chloroacetamido-C-PEG3-C3-NHBoc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Chloroacetamido-C-PEG3-C3-NHBoc
  • HY-138462
    Methyl acetate-PEG2-propanol 3026669-97-3
    Methyl acetate-PEG2-propanol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyl acetate-PEG2-propanol
  • HY-132029
    Benzyl-PEG6-amine 86770-78-7
    Benzyl-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG6-amine
  • HY-141294
    PEG3-bis(phosphonic acid) 254762-10-2
    PEG3-bis(phosphonic acid) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    PEG3-bis(phosphonic acid)
  • HY-172125
    AMPRO-222
    AMPRO-222 is a PROTAC linker that can act as a linker of PROTAC PROTAC BRD4 Degrader-29 (HY-172124).
    AMPRO-222
  • HY-138479
    Benzyl-PEG2-ethanol 2055300-50-8
    Benzyl-PEG2-ethanol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG2-ethanol
  • HY-140787
    Azide-PEG6-amido-C16-Boc
    Azide-PEG6-amido-C16-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG6-amido-C16-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG6-amido-C16-Boc
  • HY-140838
    Boc-NH-PEG6-azide 1292268-15-5
    Boc-NH-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-NH-PEG6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Boc-NH-PEG6-azide
  • HY-140371
    Tos-PEG12-Tos 1456708-45-4
    Tos-PEG12-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG12-Tos
  • HY-116186
    m-PEG5-MS 130955-38-3
    m-PEG5-MS is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG5-MS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    m-PEG5-MS
  • HY-141097
    Acid-PEG13-NHS ester 2152679-62-2
    Acid-PEG13-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Acid-PEG13-NHS ester
  • HY-138441
    Boc-NH-PEG11-NHS ester
    Boc-NH-PEG11-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG11-NHS ester
  • HY-140789
    Azide-PEG9-amido-C8-Boc
    Azide-PEG9-amido-C8-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG9-amido-C8-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG9-amido-C8-Boc
PROTAC Linkers Isoform Comparison

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